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Contraindicated (1)pentobarbital decreases amounts of vandetanib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Stay away from coadministration with strong CYP3A4 inducers; these drugs cut down publicity to vandetanib by as many as forty%.pentobarbital will decrease the extent or result of pimozide by affecting hepatic

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